| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 07-11-25 19:00 | FC Twente Enschede | Telstar | 0:0 |
| 08-11-25 15:30 | Excelsior Roterdão | Heracles Almelo | 1:2 |
| 08-11-25 17:45 | FC Volendam | NAC Breda | 2:1 |
| 08-11-25 19:00 | Fortuna Sittard | SC Heerenveen | 2:0 |
| 08-11-25 20:00 | PEC Zwolle | Sparta Roterdão | 1:0 |
| 09-11-25 11:15 | FC Utrecht | Ajax Amsterdão | 2:1 |
| 09-11-25 13:30 | NEC Nijmwegen | FC Groningen | 2:0 |
| 09-11-25 15:45 | AZ Alkmaar | PSV Eindhoven | 1:5 |
| 09-11-25 19:00 | Go Ahead Eagles Deventer | Feyenoord Rotterdão | 2:1 |